The Detox Drip with Glutathione: A New Approach to Healing From Chronic Illness Part 2

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Glutathione Body Detoxification

Chemical Detoxification

Glutathione Detoxification

Similarly, Dr. Patricia Kane and Dr. Neil Speight believe they have developed an effective approach to chronic fatigue, lyme disease and neurological illnesses by detoxifying the body with intravenous glutathione and intravenous lipids. As they write in the Townsend newsletter, “GSH infusion by fast intravenous push has been a remarkable tool to unload the body burden of heavy metals and neurotoxins in both pediatric and adult patients.” In my own practice, I add glutathione as a “chaser” (at the very end of a detox drip, to help prevent any oxidation—since glutathione oxidizes easily when exposed to air or in the presence of certain minerals).

I have given this to patients with multiple sclerosis, chronic fatigue, HIV, lyme disease, Guillain-Barre syndrome, hepatitis C, or just garden variety stress and fatigue. One hepatitis C patient’s liver values returned to normal and she resumed a full teaching schedule at her university after a series of detox drips. Another patient with chronic lyme disease finds that weekly detox drips with glutathione improve her neurological symptoms of buzzing, burning and fatigue. My own nurse uses glutathione in fighting off colds. Because oral glutathione is not well absorbed, I have also begun to experiment with nebulized glutathione, which patients can take at home between detox drips.

According to a study in Alternative Medicine Review in 2000, nebulized glutathione has had remarkable success in emphysema and other lung disorders such as asthma and bronchitis. It appears that inhalation may have a systemic effect. Some patients are having even greater success with this combination. Michelle Alpert can be reached by emailing her at drmichellealpert@yahoo.com or calling her office at 212-675-9343. Where to get glutathione: Preservative-free intravenous glutathione is available from Wellness Pharmacy in Alabama, (800) 880-5882. Wellness Pharmacy also offers glutathione in nasal sprays and oral formulations.

For those who do not have access to treatment with intravenous glutathione, whey protein has been found to increase cellular glutathione. Sublingual glutathione is available, and although there are no solid studies proving its effectiveness, it may be helpful. Nebulized glutathione can be used at home under your doctor’s guidance. Key Pharmacy (800-878-1322) can provide glutathione in this form, along with a nebulizer, both by prescription.

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Liver Detoxification & Glutathione Part 2

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Phase I Detoxification
In order to neutralize unwanted chemicals, the liver uses two-step enzymatic process. Phase I pathway converts a toxic chemical into a less harmful chemical. This is achieved by various chemical reactions (such as oxidation, reduction and hydrolysis), and during this process free radicals are produced which, if excessive, can damage the liver cells.

Without adequate free radical defenses, every time the liver neutralizes a toxin exposure, it is damaged by the free radicals produced. Antioxidants reduce the damage caused by these free radicals. If antioxidants are lacking and toxin exposure is high, toxic chemicals become far more dangerous. Some may be converted from relatively harmless substances into potentially carcinogenic substances.

The most important antioxidant for neutralizing the free radicals produced in phase I is glutathione.
Phase II Detoxification
This is called the conjugation pathway, whereby the liver cells add another substance (eg. cysteine, glycine or a sulphur molecule) to a toxic chemical or drug, to render it less harmful. This makes the toxin or drug water-soluble, so it can then be excreted from the body via watery fluids such as bile or urine. Individual xenobiotics and metabolites usually follow one or two distinct pathways.

There are essentially six phase II detoxification pathways:
• Glutathione conjugation
• Amino acid conjugation
• Methylation
• Sulfation
• Acetylation
• Glucuronidation

Through conjugation, the liver is able to turn drugs, hormones and various toxins into excretable substances. For efficient phase II detoxification, the liver cells require sulphur-containing amino acids such as taurine and cysteine. The nutrients glycine, glutamine, choline and inositol are also required for efficient phase II detoxification.

Glutathione is also critically involved in the phase II detoxification processes. If high levels of toxin exposure produce so many free radicals from phase I detoxification that the glutathione is depleted, the phase II processes dependent upon glutathione stop, producing oxidative stress or liver damage.

The toxins transformed into activated intermediates by phase I are substantially more reactive than the phase I toxins were. Unless quickly removed from the body by phase II detoxification mechanisms, they can cause widespread problems, especially carcinogenesis. Therefore, the rate at which phase I produces activated intermediates must be balanced by the rate at which phase II finishes their processing.

People with a very active phase I detoxification system coupled with slow or inactive phase II enzymes are termed pathological detoxifiers. These people suffer unusually severe toxic reactions to environmental poisons. A liver detoxification test can pinpoint exactly how efficiently your liver is carrying out the detoxification process and if you are a pathological detoxifier.

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The Glutathione Body Detoxification Part 2

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Basically it protects us in two ways. One, it detoxifies or helps remove toxins when they enter the body and subsequently the individual cells in the organs. So after the attack it goes to work removing the toxins.

When a person overdoses on Tylenol, in the hospital ED or ER Doctor will administer NAC, a drug that promotes the production of Glutathione.

Secondly Glutathione body detoxification acts to protect the cell from the invading toxins. So rather than waiting till your sick, this is in effect preventative medicine (in the metaphorical sense). This is providing the body with the resources it needs to fight the enemy toxin insurgents.

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The Glutathione Body Detoxification Part 1

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Daily we are attacked by enemy insurgents. The intercellular glutathione body detoxification is one of the body’s most important defense systems. Unfortunately few even know of it.
Scientific studies have shown that glutathione (GSH) has multiple detoxification functions. Depletion of glutathione is associated with increased risk of chemical toxicity.
What are Toxins is a brief look at the definition. Also, what are toxicants?
We also know that glutathione can be depleted from doing its job, from some medications and agents, and lack of intake of the essential building blocks and co-factors.
Age, race, gender and diet are all factors in the GSH levels in the body.
Currently Tylenol toxicity is treated by boosting glutathione levels in the body with the drug NAC. Scientist now believe that boosting glutathione levels will also be the treatment of choice for detoxifying carbon monoxide poisoning, carbon tetrachloride, chloroform and other types of poisonous compounds, chemicals and gasses.
First and Foremost
The most important health and wellness self promotion step we can take is avoidance of those things that are harmful to the body.
This includes cigarette smoke, tobacco products, house hold cleaners and detergents, dry-cleaned clothes, new carpeting, some plastic food containers, and furniture to name a few within our homes. Outside would include pesticides and fertilizers for our flowers and grass, smog, parking garage and even the corner of a busy street. The stopping of cars releases high amounts of asbestos in the air which you breathe.
It only gets worse in the office. There are copier fluids and other chemicals in the furniture and carpeting to name a few.
The reality is impossible in the world we live and spend every day. This means to have optimal health we need to employ other means of protection.
How does Glutathione body detoxification protect us from the various toxins?
There is no simple answer.

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Liver Detoxification & Glutathione Part 1

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The liver is one of the most important organs in the body when it comes to detoxifying of toxic substances, especially from the gut. By a complex series of enzymatic reactions, the liver is able to detoxify many harmful substances. Most of the detoxification process involves converting fat soluble toxins into water soluble substances that can be excreted in the urine or the bile.

Many of the toxic chemicals that enter the body are fat-soluble, this makes them difficult for the body to excrete. Fat soluble chemicals have a high affinity for fat tissues and cell membranes. In these fatty tissues of the body, toxins may be stored for years, being released during times of exercise, stress or fasting. During the release of these toxins, several symptoms such as headaches, poor memory, stomach pain, nausea, fatigue, dizziness and palpitations can occur.
Proper functioning of the liver’s detoxification systems is especially important for the prevention of cancer. Up to 90% of all cancers are thought to be due to the effects of environmental carcinogens, such as those in cigarette smoke, food, water, and air, combined with deficiencies of the nutrients the body needs for proper functioning of the detoxification and immune systems.

The liver plays several roles in detoxification: it filters the blood to remove large toxins, synthesizes and secretes bile full of cholesterol and other fat-soluble toxins, and enzymatically disassembles unwanted chemicals. This enzymatic process usually occurs in two steps referred to as phase I and phase II. Phase I either directly neutralizes a toxin, or modifies the toxic chemical to form activated intermediates which are then neutralized by one of more of the several phase II enzyme systems.

When metabolic processes are normal, the production of a wide range of chemicals and hormones is consistent, the liver has no problem to neutralize them efficiently. However, when metabolic processes go awry as it is typically as a result of nutritional deficiencies, the level and type of internally produced toxins increases greatly. These non-end-product metabolites have become a serious problem in this age of conventionally grown crops, fast foods and poor diets.

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